Search results
Search for "cell damage" in Full Text gives 12 result(s) in Beilstein Journal of Nanotechnology.
Exploring the relationships between physiochemical properties of nanoparticles and cell damage to combat cancer growth using simple periodic table-based descriptors
Beilstein J. Nanotechnol. 2024, 15, 297–309, doi:10.3762/bjnano.15.27
- new ways for modeling the structural properties and bio-toxic effects of NMs. The goal of the study is to construct fully validated property-based models to extract relevant features for estimating and influencing the zeta potential and obtaining the toxicity profile regarding cell damage in the
- lack such information. To further clarify the influence of the zeta potential on cell damage, a QSPR model was developed with 132 MeOx NMs to understand the possible mechanisms of cell damage. The results showed that zeta potential, along with seven other descriptors, had the potential to influence
- ; cell damage; MeOx NMs (metal oxide nanomaterials); nano-QSPR; zeta potential; Introduction Engineered nanoparticles have become an integral part of our daily lives in consumable products and commercial goods. Their versatile tunable properties have made nanomaterials a center of innovation in
Overview of mechanism and consequences of endothelial leakiness caused by metal and polymeric nanoparticles
Beilstein J. Nanotechnol. 2023, 14, 329–338, doi:10.3762/bjnano.14.28
- common causes of cell damage including endothelium damage [6][14]. An increased ROS concentration closely correlates with the amount of pro-inflammatory cytokines, whose participation has been confirmed to increase endothelial permeability. Histamine and bradykinin are among the pro-inflammatory
Bismuth-based nanostructured photocatalysts for the remediation of antibiotics and organic dyes
Beilstein J. Nanotechnol. 2023, 14, 291–321, doi:10.3762/bjnano.14.26
- threat to both human and ecological health. The active ingredients of antibiotics and their fragments may cause kidney and liver cell damage in humans if they are exposed to antibiotic residues for an extended time [63][64][65]. Additionally, it has been noted that prolonged exposure to antibiotic
Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications
Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64
- ]. In other cases, disruption and destabilization of the complex nanostructure subsequent to US vibration leads to drug release [28][29][30]. In addition, the ultrasonication of certain complexes can generate free radicals that can cause cell damage or activation of cellular signaling pathways [31
- generation are recognized as the mechanism of action of US-responsive nanomaterials. These nanomaterials can act through at least one of the mechanisms. Cargo release, drug activation, cell damage, and enhanced cargo penetration, in addition to contrast enhancement, are the clinically practical consequences
Characterization, bio-uptake and toxicity of polymer-coated silver nanoparticles and their interaction with human peripheral blood mononuclear cells
Beilstein J. Nanotechnol. 2021, 12, 282–294, doi:10.3762/bjnano.12.23
- samples using ICP-MS. Measurements of viability and metabolic activity of cells To investigate the cytotoxicity of Ag on PBMCs we used two different assays that measure cell damage (LDH assay) and metabolic activity (MTS assay). LDH is a colorimetric assay that measures the membrane integrity and
Antimicrobial metal-based nanoparticles: a review on their synthesis, types and antimicrobial action
Beilstein J. Nanotechnol. 2020, 11, 1450–1469, doi:10.3762/bjnano.11.129
- and understanding of the antimicrobial action of metal-based nanoparticles are key topics, several methods for evaluating in vitro antimicrobial activity and the most common antimicrobial mechanisms (e.g., cell damage and changes in the expression of metabolic genes) were discussed in this review
- microorganisms [145][147][148]. In general, both mentioned methodologies are the most common techniques used. In case more information is needed regarding the inhibitory effect (bactericidal or bacteriostatic) or the cell damage caused by the NPs against the target microorganism, dead time tests and flow
- death. The combination of oxidative stress, metal ion release, and non-oxidative damage affects cell structures upon NP exposure in several ways. In the following sections, these cell damage cases will be briefly explained. Cell wall damage The bacterial cell wall provides rigidity, shape, and
The systemic effect of PEG-nGO-induced oxidative stress in vivo in a rodent model
Beilstein J. Nanotechnol. 2019, 10, 901–911, doi:10.3762/bjnano.10.91
- scavenging enzyme that converts hydrogen peroxide (H2O2) into water and oxygen, thus preventing cell damage. A reduction of the acitivity of CAT after PEG-nGO administration was observed as shown in Table 2. One hour after PEG-nGO administration, the decrease in CAT enzyme activity was significant (P* < 0.05
Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations
Beilstein J. Nanotechnol. 2018, 9, 1050–1074, doi:10.3762/bjnano.9.98
Low uptake of silica nanoparticles in Caco-2 intestinal epithelial barriers
Beilstein J. Nanotechnol. 2017, 8, 1396–1406, doi:10.3762/bjnano.8.141
- may cause cell damage [36][38]. This is unlikely to happen in any realistic nanoparticle exposure scenario, where biomolecules adsorb to the nanoparticle to form a nanoparticle biomolecular corona which effectively protects the cells from such immediate damage [39][40][41]. Though the intestinal lumen
On the pathway of cellular uptake: new insight into the interaction between the cell membrane and very small nanoparticles
Beilstein J. Nanotechnol. 2016, 7, 1296–1311, doi:10.3762/bjnano.7.121
- observed in Figure 6. In contrast, the toxic threshold surface area from LDH measurements is 0.18 m2·mL−1 for SiNP-7, only. However, the surface area interacting with the cell membrane is considerably smaller due to the tubular uptake morphology. This indicates that here the mechanism of cell damage cannot
Interaction of dermatologically relevant nanoparticles with skin cells and skin
Beilstein J. Nanotechnol. 2014, 5, 2363–2373, doi:10.3762/bjnano.5.245
- stress and cell damage. The results are in accordance with reports in the literature, e.g., differential tolerance to AgNP depending on chloride concentrations and ionic strength and Ag+-induced oxidative stress in E. coli was recently demonstrated by Chambers et al. [41]. Biological responses to
Different endocytotic uptake mechanisms for nanoparticles in epithelial cells and macrophages
Beilstein J. Nanotechnol. 2014, 5, 1625–1636, doi:10.3762/bjnano.5.174
- observed in J774A.1 macrophages but not in A549 epithelial cells for the given exposure time of 1 hour. A549 cells required a much longer time of 1 hour to internalize 1 µm particles (data not shown). However, since the inhibitors began to induce cell damage after 1 to 1.5 hours, observation time could not
- addition, other inhibitors such as statins, filipin or nystatin could be used, however, severe cell damage for those three inhibitors has been observed in earlier studies [32]. In A549 epithelial cells, the macropinocytosis and phagocytosis pathways could not be explored, as the uptake of 1 µm particles by
Other Beilstein-Institut Open Science Activities
